Clinical Trial

PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717

Recruiting Phase 1/2
View on ClinicalTrials.gov →
Summary
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of intrathecal (IT) delivery of ION717.
Protocol Amendment History 28 amendments
This ClinicalTrials.gov record has been amended 28 times since 2023-11-29; most recent amendment 2026-04-23.
Status change: Active, Not Recruiting → Recruiting 2026-03-13
Status change: Recruiting → Active, Not Recruiting 2024-12-24
Status change: Active, Not Recruiting → Recruiting 2024-08-15
Status change: Recruiting → Active, Not Recruiting 2024-04-06
Status change: Not Yet Recruiting → Recruiting 2023-12-19
Trial Details
NCT Number NCT06153966
Lead Sponsor Ionis Pharmaceuticals, Inc.
Conditions Prion Disease
Enrollment 76 participants
Start Date 2024-01-04
Primary Completion 2027-02 (estimated)
Study Completion 2030-06 (estimated)
Updated on ClinicalTrials.gov 2026-08-05