Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement

The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in subjects affected by severe periodontitis; to evaluate if microbiome changes in relation to the used of different implant material/surface; and to assess the variance of the changes to determine the sample size for future longitudinal prospective studies.

NCT Number	NCT06149585
Lead Sponsor	Case Western Reserve University
Conditions	Edentulous Mouth, Periodontal Diseases, Periodontitis, Adult, Microbial Colonization
Enrollment	12 participants
Start Date	2023-08-16
Primary Completion	2027-05-01 (estimated)
Study Completion	2028-05-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-01