Clinical Trial

Salivary Biomarkers for Concussion

Study acronym: SportCo
Recruiting
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Record status
This record was last updated March 16, 2026 (before its estimated June 12, 2026 completion). Its status may not reflect the trial's current state.
Summary
Concussion (CC) (also called mild head trauma), which accounts for 85% of all head injuries, is very common in professional and amateur athletes. CC is an injury to the brain resulting from the direct or indirect impact of external mechanical forces, momentarily disrupting its function on a cellular level. Unlike more serious head injury (moderate and severe), which can be diagnosed using neuroimaging techniques (CT, MRI, etc.), patients suffering from CC do not necessarily show visible signs of structural abnormalities. As a result, diagnosis of CC is offen difficult. Recently, several salivary biomarkers (proteins and nucleic acids) of sport related concussion have been identified in professional athletes. However, their reference values have not been determined with sufficient robustness to enable their employment in concussion diagnostic tests.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2023-11-22; most recent amendment 2026-03-12.
Status change: Not Yet Recruiting → Recruiting 2026-02-02
Trial Details
NCT Number NCT06149351
Lead Sponsor Sys2Diag
Collaborators: Centre National de la Recherche Scientifique, France
Conditions Sport Related Concussion
Enrollment 80 participants
Start Date 2023-12-12
Primary Completion 2026-06-12 (estimated)
Study Completion 2027-12-12 (estimated)
Updated on ClinicalTrials.gov 2026-03-16