Antibiotics and Vaccine Immune Responses Study

The goal of this clinical trial is to examine immune responses to the BCG vaccine in healthy adults who have, or who have not, taken antibiotics to deplete their gut bacteria prior to vaccination. The main question it aims to answer is: does depletion of the gut microbiota lead to impaired BCG-induced protection against specific and non-specific to challenges to the immune system?

NCT Number	NCT06148025
Lead Sponsor	South Australian Health and Medical Research Institute Collaborators: Royal Adelaide Hospital, Flinders University, University of Sydney, Telethon Kids Institute, Centenary Institute
Conditions	Vaccine Response Impaired
Enrollment	348 participants
Start Date	2023-11-23
Primary Completion	2027-10-01 (estimated)
Study Completion	2028-10-01 (estimated)
Updated on ClinicalTrials.gov	2025-12-10