Prophylactic Tributyrin Supplementation in Acute Pancreatitis

The goal of this clinical trial is to investigate the possible effects of tributyrin supplementation in patients with a first episode of acute pancreatitis. The main question it aims to answer is: • The effect of oral tributyrin supplementation on the plasma endotoxin level Participants will be randomized between two groups: intervention and control group. They will receive: \- three times daily 4grams of micro-encapsulated granules of tributyrin, and the control group three times daily 4 grams of micro-encapsulated sunflower oil (i.e. placebo), for a total of 14 days In total 92 adult patients with a first episode of acute pancreatitis will be included.

NCT Number	NCT06147635
Lead Sponsor	St. Antonius Hospital
Conditions	Acute Pancreatitis
Enrollment	92 participants
Start Date	2024-02-12
Primary Completion	2026-10 (estimated)
Study Completion	2027-01 (estimated)
Updated on ClinicalTrials.gov	2024-06-20