Clinical Trial

Prescription of Letrozole for Uterine Myoma

Study acronym: PLUM
Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
The PLUM Study is a randomized, double-blinded, 2-arm, parallel-group, placebo-controlled trial is designed to compare the efficacy of letrozole versus placebo on leiomyoma-related symptoms and quality of life as well as leiomyoma and uterine size.
Protocol Amendment History 6 changes
notable Primary completion pushed: 2027-09-06 -> 2028-09-11 2026-07-23
minor Completion pushed: 2027-12-13 -> 2028-12-11 2026-07-23
notable Primary completion pushed: 2027-06-30 -> 2027-09-06 2026-05-21
minor Completion pushed: 2027-06-30 -> 2027-12-13 2026-05-21
notable Primary completion pushed: 2027-01-30 -> 2027-06-30 2026-04-30
minor Completion pushed: 2027-04-30 -> 2027-06-30 2026-04-30
Trial Details
NCT Number NCT06143631
Lead Sponsor University of California, San Francisco
Collaborators: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions Leiomyoma, Uterine, Leiomyoma, Fibroid, Fibroid Uterus
Enrollment 140 participants
Start Date 2024-07-24
Primary Completion 2028-09-11 (estimated)
Study Completion 2028-12-11 (estimated)
Updated on ClinicalTrials.gov 2026-07-22