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Mechanisms of Fasting Induced Reduction in Energy Expenditure

Study acronym: FIRE
StatusRecruiting
PhaseNot applicable
SponsorETH Zurich
Started
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Record status
This record was last updated May 30, 2025 (before its estimated April 18, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Primary and study completion dates: Dec 2024 to Apr 18, 2026
    • Study description expanded, about 85 words
    v3
  2. Start date changed from estimate of Nov 2023 to Nov 15, 2023v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
ETH Zurich
15 trials monitored
See 1 trial at risk
Fasting reduces the energy consumption of the human body. The extent of this adaptation varies significantly between different individuals. The aim of this research project is to investigate how this adaptation of the metabolism is regulated by the body. For this purpose, we will first measure how the so-called basal metabolic rate of the body reacts to a short-term fasting of 24 h in a preliminary study. Those subjects with a particularly pronounced and those subjects with an only slightly pronounced reaction of the basal metabolic rate will be invited to the main study. Here, in random order (24 h fasting vs. 8 h fasting), the following is compared * how the basal metabolic rate of the body reacts to the reduced energy intake. * how the energy metabolism increases after a test meal * what role in particular the thyroid hormones play in this adaptation. In addition, a sample of the subcutaneous adipose tissue is taken in each case and it is examined how the regulation of metabolic processes at the cellular level.
Trial Details
NCT Number NCT06134258
Lead Sponsor ETH Zurich
Collaborators: University Hospital, Basel, Switzerland
Conditions
(from sponsor)		 Fasting
Related terms Fasting
Enrollment 40 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov