Mechanisms of Fasting Induced Reduction in Energy Expenditure

Fasting reduces the energy consumption of the human body. The extent of this adaptation varies significantly between different individuals. The aim of this research project is to investigate how this adaptation of the metabolism is regulated by the body. For this purpose, we will first measure how the so-called basal metabolic rate of the body reacts to a short-term fasting of 24 h in a preliminary study. Those subjects with a particularly pronounced and those subjects with an only slightly pronounced reaction of the basal metabolic rate will be invited to the main study. Here, in random order (24 h fasting vs. 8 h fasting), the following is compared * how the basal metabolic rate of the body reacts to the reduced energy intake. * how the energy metabolism increases after a test meal * what role in particular the thyroid hormones play in this adaptation. In addition, a sample of the subcutaneous adipose tissue is taken in each case and it is examined how the regulation of metabolic processes at the cellular level.

NCT Number	NCT06134258
Lead Sponsor	ETH Zurich Collaborators: University Hospital, Basel, Switzerland
Conditions	Fasting
Enrollment	40 participants
Start Date	2023-11-15
Primary Completion	2026-04-18 (estimated)
Study Completion	2026-04-18 (estimated)
Updated on ClinicalTrials.gov	2025-05-30