Clinical Trial

Fisetin to Improve Vascular Function in Older Adults

Active, Not Recruiting Phase 1/2
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Record status
This record was last updated November 12, 2025 (before its estimated March 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
This is a pilot clinical trial to test the efficacy of intermittent treatment with the flavonoid compound fisetin for improving vascular endothelial function and reducing aortic stiffness in older adults. This trial will also determine the potential mechanisms by which fisetin may improve vascular function, including by decreasing mitochondrial oxidative stress, cellular senescence and senescence-associated secretory phenotype (SASP) factors in circulation. Lastly, safety, tolerability and adherence of fisetin treatment will be assessed.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2023-11-10; most recent amendment 2025-11-07.
Status change: Recruiting → Active, Not Recruiting 2025-11-07
Trial Details
NCT Number NCT06133634
Lead Sponsor University of Colorado, Boulder
Collaborators: American Heart Association
Conditions Aging, Endothelial Dysfunction, Arterial Stiffness
Enrollment 70 participants
Start Date 2023-09-25
Primary Completion 2026-03-31 (estimated)
Study Completion 2027-03-31 (estimated)
Updated on ClinicalTrials.gov 2025-11-12