Clinical Trial

Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression

Study acronym: DBA
Recruiting
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Record status
This record was last updated March 11, 2026 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. In our previous research, we found that anhedonia decreases goal-directed behavior and its related neural activity. In this study, we will investigate target engagement from five-consecutive days of stimulation for participants that are within a unipolar major depressive episode and also have high symptoms of anhedonia.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2023-11-09; most recent amendment 2026-03-09.
Status change: Not Yet Recruiting → Recruiting 2024-01-10
Trial Details
NCT Number NCT06132581
Lead Sponsor Florida State University
Collaborators: National Institute of Mental Health (NIMH)
Conditions Major Depressive Disorder, Anhedonia
Enrollment 72 participants
Start Date 2024-01-24
Primary Completion 2026-07-31 (estimated)
Study Completion 2026-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-03-11