Clinical Trial

Oral Health and Adverse Pregnancy Complications

Recruiting
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Record status
This record was last updated March 30, 2025 (before its estimated November 2025 completion). Its status may not reflect the trial's current state.
Summary
Pregnant women are susceptible to develop periodontitis, but these oral health changes related to pregnancy are often neglected. Periodontitis is accompanied by a low-grade systemic inflammation and can be harmful to the general health of the woman, contribute to pre-term birth and adversely influence the future health and metabolism of the offspring. Despite this, studies indicate that 40% of Danish women in childbearing age do not visit a dentist regularly. The PROBE controlled intervention study will investigate the beneficial effect of treatment of periodontal disease during pregnancy on fetal growth, preterm delivery and birth weight.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2023-10-25; most recent amendment 2025-03-25.
Trial Details
NCT Number NCT06110143
Lead Sponsor University Hospital Bispebjerg and Frederiksberg
Conditions Periodontal Diseases, Pregnancy Complications, Pregnancy Preterm, Gestational Diabetes, Preeclampsia, Inflammation
Enrollment 600 participants
Start Date 2021-11-13
Primary Completion 2025-11 (estimated)
Study Completion 2026-05 (estimated)
Updated on ClinicalTrials.gov 2025-03-30