Clinical Trial

Study Comparing Platelet Transfusion Volumes in Premature Babies

Study acronym: PlaNeT-3
Not Yet Recruiting
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Summary
Platelet transfusions can help clotting but may also have risks. Currently when babies get platelet transfusions they get as much as three times (per kilogram of body weight) as much as adults do. The goal of this clinical trial is to to find out which volume of platelets should be transfused to premature babies with low platelets and no bleeding. The main question it aims to answer is if a smaller volume for platelet transfusion can help prevent death and severe bleeding and also have fewer side effects for the baby. Participants will be placed at random into one of two groups: In Group 1, babies will get a platelet transfusion based on the volume of 5mls/kg weight, in Group 2, babies will get a platelet transfusion based on the volume of 15mls/kg weight. Babies will remain in their allocated group during their stay on the neonatal unit so that they always receive the allocated volume unless a clinician decides otherwise.
Trial Details
NCT Number NCT06095648
Lead Sponsor University College Dublin
Collaborators: Health Research Board, Ireland, National Maternity Hospital, Ireland, Irish Blood Transfusion Service
Conditions Thrombocytopenia, Transfusion
Enrollment 370 participants
Start Date 2023-10-28
Primary Completion 2026-08 (estimated)
Study Completion 2028-08 (estimated)
Updated on ClinicalTrials.gov 2023-10-23