A Retrospective Analysis of Outcomes in Patients With Hepatorenal Syndrome at Methodist Dallas Medical Center

Hepatorenal syndrome (HRS) is a common cause of acute kidney injury (AKI) in patients with liver disease \[1\]. Increased activity and presence of vasodilators such as nitric oxide in cirrhotic patients leads to vasodilation, especially in the splanchnic circulation, resulting in hemodynamic changes that precipitate renal injury \[1\]. Patients may present with elevated serum creatinine (Cr), benign urine sediment, and low urine sodium \[1\].

NCT Number	NCT06095440
Lead Sponsor	Methodist Health System
Conditions	Hepatorenal Syndrome
Enrollment	500 participants
Start Date	2023-05-13
Primary Completion	2027-05-13 (estimated)
Study Completion	2027-05-13 (estimated)
Updated on ClinicalTrials.gov	2026-05-01