dTMS for Subjective Cognitive Decline

Deep transcranial magnetic stimulation (dTMS) is a brain stimulation technique that involves generating a brief magnetic field in a coil that is placed on the scalp. The magnetic field passes through the skull and induces a weak electrical current in the brain that briefly activates neural circuits at the stimulation site. The Brainsway dTMS H7-Coil is able to target an area of the brain that has been shown in studies to be linked to greater resilience to cognitive decline. In this study, the investigators will combine dTMS with cognitive training in older adults with subjective cognitive decline (SCD) and examine the effect of this treatment on memory, other cognitive abilities, and mood. In addition, the investigators will examine the combined effects of dTMS and cognitive training on brain activity as measured using electroencephalography (EEG). Approximately 30 older adults from ages 55 to 70 with SCD and a positive family history of Alzheimer's disease will be enrolled in this study.

NCT Number	NCT06095063
Lead Sponsor	Rotman Research Institute at Baycrest Collaborators: Brainsway, Centre for Addiction and Mental Health
Conditions	Alzheimer Disease, Subjective Cognitive Decline
Enrollment	30 participants
Start Date	2023-11-15
Primary Completion	2026-10-01 (estimated)
Study Completion	2026-11-15 (estimated)
Updated on ClinicalTrials.gov	2025-10-27