Clinical Trial

Probiotics to Actively Counter Ventilator Associated Pneumonia (PROACT)

Study acronym: PROACT
Recruiting
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Record status
This record was last updated September 23, 2025 (before its estimated July 15, 2026 completion). Its status may not reflect the trial's current state.
Summary
PROACT study aims to resolve uncertainties to influence actual practice guidelines or public health policing regarding VAP prevention in ICU by using probiotics administration. Multi-trauma patients with a head injury OR stroke or brain haemorrhage patients without any sign of aspiration and lung infection will be enrolled and randomized to either placebo or probiotic treatment to assess if VAP and mortality can be reduced in the interventional group.
Protocol Amendment History 11 amendments
This ClinicalTrials.gov record has been amended 11 times since 2023-10-15; most recent amendment 2025-09-17.
Status change: Not Yet Recruiting → Recruiting 2023-12-01
Trial Details
NCT Number NCT06092554
Lead Sponsor University of Bari
Collaborators: Uni-Pharma
Conditions Ventilator Associated Pneumonia
Enrollment 186 participants
Start Date 2023-12-13
Primary Completion 2026-07-15 (estimated)
Study Completion 2026-07-15 (estimated)
Updated on ClinicalTrials.gov 2025-09-23