Supplementation for Male Subfertility

Old age, obesity, physical inactivity, environmental factors and genetics may contribute negatively to fertility in both males and females. In males, specifically, certain supplements, such as single antioxidants and trace minerals, have previously been shown to improve sperm function marginally. One hypothesis is that sperm function can be improved even further by combining several different types of supplements (e.g., amino acids, energy carriers, vitamins, antioxidants, and trace minerals) to target several age-related cell pathways, for example, oxidative stress, mitochondrial dysfunction, inflammation and cell energetics. This 3-month placebo-controlled, randomized clinical trial, aims to test the effects of a novel multi-ingredient supplement (Fertility Enhancer) that targets several age-related cell pathways on sperm function in overweight or obese and subfertile males.

NCT Number	NCT06091969
Lead Sponsor	Hamilton Health Sciences Corporation Collaborators: One Fertility
Conditions	Male Infertility
Enrollment	64 participants
Start Date	2025-01-01
Primary Completion	2026-02-02 (estimated)
Study Completion	2026-02-02 (estimated)
Updated on ClinicalTrials.gov	2024-10-10