Cryoneurolysis for Acute Postoperative Pain Following Total Knee Arthroplasty

Cryoneurolysis is a regional anaesthetic technique that works by freezing peripheral sensory nerves. This technique can potentially provide analgesia after total knee arthroplasty (TKA). However, the technique is expensive and comprehensive. Pain 24 hours after surgery is associated with high amounts of late acute pain. Therefore, the aim of the current study was to compare the effect of postoperative cryoanalgesia with a sham treatment on acute postoperative pain in TKA patients with moderate to severe pain on the first postoperative day. The cryoanalgesia treatment will be performed 24 hours after surgery. Afterward, the patients will be followed for 24 weeks to determine the level of pain among other outcomes.

NCT Number	NCT06088602
Lead Sponsor	Copenhagen University Hospital, Hvidovre Collaborators: Rigshospitalet, Denmark
Conditions	Acute Postoperative Pain
Enrollment	44 participants
Start Date	2024-03-19
Primary Completion	2025-06 (estimated)
Study Completion	2025-10 (estimated)
Updated on ClinicalTrials.gov	2024-07-16