Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi

This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent preventive treatment with dihydroartemisinin-piperaquine (IPT-DP). Arm 2: Intermittent preventive treatment with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) (IPT-SPAQ). Arm 3: Control - students will receive standard of care (no preventive treatment). Outcomes include P. falciparum infection and parasite density, anemia, cognitive function and educational testing, as well as infection prevalence and disease incidence in young children sleeping student's households to assess the impact on transmission.

NCT Number	NCT06083688
Lead Sponsor	Liverpool School of Tropical Medicine Collaborators: Kamuzu University of Health Sciences
Conditions	Malaria,Falciparum, Anemia in Children
Enrollment	788 participants
Start Date	2024-10-14
Primary Completion	2025-07-31 (estimated)
Study Completion	2026-01-14 (estimated)
Updated on ClinicalTrials.gov	2026-07-30