Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT06083480 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

StatusRecruiting
PhasePhase 4
Started2024-12-06
View on ClinicalTrials.gov ↗

Amendment history

2025-12-05
Study Status, Oversight v7
Re-verified, no change to tracked fields
2024-12-06
Study Status v6
Start dateestimated 2024-12→confirmed 2024-12-06
2024-12-04
Not Yet Recruiting→Recruiting Study Status, Oversight, Contacts/Locations v5
Trial statusNot Yet Recruiting→Recruiting
Start date2024-11-15→2024-12
Study sitesdetails revised at 1 of 1 site
2024-10-03
Study Status, Oversight v4
Start date2024-09-02→2024-11-15
2024-07-08
Study Status v3
Start date2024-06-15→2024-09-02
Show 2 earlier versions
2024-04-29
Study Status v2
Start date2024-03→2024-06-15
2023-11-15
Study Identification, Study Status, Outcome Measures v1
Secondary endpoints6 to 10 entries
Postsurgical Opioid Use (pill count) Postsurgical Opioid Use (days of opioid use in the past week) F2-Isoprostane/Isofuran (IsoP/IsoF) levels Glutathione levels
2023-10-10
Original filing
This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent antioxidant intervention (glycine + N-acetyl-cysteine(GlyNAC)) reduces oxidative stress and chronic post surgical pain (CPSP) in patients undergoing total knee arthroplasty (TKA).
Trial Details
NCT Number NCT06083480
Lead Sponsor Vanderbilt University Medical Center
Collaborators: National Institute on Aging (NIA)
Conditions Osteoarthritis, Knee, Total Knee Arthroplasty, Chronic Postsurgical Pain
Enrollment 148 participants
Start Date 2024-12-06
Primary Completion 2028-09 (estimated)
Study Completion 2029-03 (estimated)
Updated on ClinicalTrials.gov 2025-12-11