Clinical Trial

Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

Recruiting Phase 4
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Summary
This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent antioxidant intervention (glycine + N-acetyl-cysteine(GlyNAC)) reduces oxidative stress and chronic post surgical pain (CPSP) in patients undergoing total knee arthroplasty (TKA).
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2023-10-10; most recent amendment 2025-12-05.
Status change: Not Yet Recruiting → Recruiting 2024-12-04
Trial Details
NCT Number NCT06083480
Lead Sponsor Vanderbilt University Medical Center
Collaborators: National Institute on Aging (NIA)
Conditions Osteoarthritis, Knee, Total Knee Arthroplasty, Chronic Postsurgical Pain
Enrollment 148 participants
Start Date 2024-12-06
Primary Completion 2028-09 (estimated)
Study Completion 2029-03 (estimated)
Updated on ClinicalTrials.gov 2025-12-11