Curcumin Supplementation in Cervical Cancer

Brief Summary. The goal of this pilot study is to learn about the effect of curcumin supplementation in locally advanced cervical cancer patients. The main questions it aims to answer are: * Does curcumin supplementation increase the levels of p53 and apoptosis in tumor cells from cervical cancer patients? * At which dose of curcumin supplementation is the broader effect observed for p53 expression and apoptosis in tumor cells from cervical cancer patients? * Are all doses safe for supplementation? Participants will be asked to take curcumin tablets throughout their cancer treatment. Researchers will compare 6 different groups, each group will receive a different dose of curcumin with or without piperin, to see the dose with the broader effect and safety of curcumin supplementation: 1. 1 g of curcumin 2. 1 g of curcumin + piperine 3. 3 g of curcumin 4. 3 g of curcumin + piperine 5. 6 g of curcumin 6. 6 g of curcumin + piperine

NCT Number	NCT06080841
Lead Sponsor	National Institute of Cancerología Collaborators: Sabinsa Corporation
Conditions	Locally Advanced Cervical Cancer
Enrollment	30 participants
Start Date	2023-04-19
Primary Completion	2025-12 (estimated)
Study Completion	2026-03 (estimated)
Updated on ClinicalTrials.gov	2025-05-25