Study of Adrenocorticotropic Hormone on Children With Frequent Relapse or Steroid-dependent Nephrotic Syndrome: a Prospective, Multicenter, Randomized，Open-label Clinical Trial.

Primary nephrotic syndrome accounts for approximately 90% of the total number of nephrotic syndrome in childhood and it is the most common glomerular disease in children. Although treatment with steroids is useful for primary nephrotic syndrome, proving to cause frequent relapse/steroid-dependent nephrotic syndrome after treatment and the usage of immunosuppressive agents has become a new choice for the treatment of such patients. This study is a prospective, multicenter, randomized，open-label clinical trial, evaluating the efficacy and safety of steroid combined with adrenocorticotrophic hormone（ACTH） to children who with frequently relapsing or steroid-dependent nephrotic syndrome, all we wish to obtain the proper drug choice and individualized treatment options for children with nephrotic syndrome.

NCT Number	NCT06079788
Lead Sponsor	Mao Jianhua Collaborators: Tongji Hospital, Children's Hospital affiliated to Capital Institute of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Children's Hospital of Nanjing Medical University, Kunming Children's Hospital, Yuying Children's Hospital of Wenzhou Medical University, Ningbo Women & Children's Hospital
Conditions	Nephrotic Syndrome in Children
Enrollment	140 participants
Start Date	2023-11-01
Primary Completion	2026-06-30 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2023-10-12