The Effects of Antibiotic Exposure in Early Infancy on Vaccine Responses

This prospective cohort study will include 200 term children born in Landspitali University Hospital in Iceland. The cohort will be divided into four groups according to antibiotic exposure of which one is the control group. Children's immune responses to live oral rotavirus vaccine as well as conventional vaccinations given at three, five and 12 months old will be determined by measuring salivary and serologic responses. Responses will be compared between the four groups. Stool samples will also be collected from participants and the composition of the microbiome compared between the four groups.

NCT Number	NCT06079606
Lead Sponsor	Landspitali University Hospital
Conditions	Immune Responses, Antibiotic Treatment
Enrollment	200 participants
Start Date	2022-09-10
Primary Completion	2025-02-28 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-18