Clinical Trial

Total Lymphoid Irradiation as Conditioning for Pediatric Haploidentical Hematopoietic Stem Cell Transplantation

Recruiting
View on ClinicalTrials.gov →
Summary
In this comparative study, the investigators aim to compare prospective pediatric patients who receive total lymphoid irradiation (TLI) using tomotherapy with age- and disease-matched controls who receive conventional total body irradiation (TBI) as part of conditioning for haploidentical hematopoietic stem cell transplantation (HSCT) for both malignant and non-malignant diseases. The investigators shall evaluate graft failure-free, graft-versus-host disease (GVHD)-free survival, overall survival, frequency of rejection, GVHD, relapse of malignancy, adverse effects and post-transplant immunoreconstitution.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2023-10-04.
Trial Details
NCT Number NCT06075563
Lead Sponsor Hong Kong Children's Hospital
Collaborators: The University of Hong Kong, Hong Kong Sanatorium & Hospital
Conditions Hematopoietic Organs; Disorder
Enrollment 23 participants
Start Date 2023-05-29
Primary Completion 2026-12 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2025-09-10