Clinical Trial

Effect of MOPs During Orthodontic Movement in Periodontitis Patients

Study acronym: MOPorthoperi
Recruiting
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Record status
This record was last updated March 27, 2025 (before its estimated October 2025 completion). Its status may not reflect the trial's current state.
Summary
Micro-osteoperforations (MOPs) cause cortical bone injuries and consequently increase the expression of inflammatory mediators, allowing for increased bone and periodontal ligament remodeling associated with orthodontic movement. It remains unclear the effect of orthodontic intrusion combined with MOPs application on teeth with reduced periodontium. The general objective will be to determine the efficacy of MOPs during orthodontic tooth movement (OTM) in terms of periodontal and orthodontic outcomes in stage IV periodontitis patients, case type 2 with pathological tooth migration (PTM), characterized the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabony component \<5mm)
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2023-09-28; most recent amendment 2025-03-24.
Trial Details
NCT Number NCT06068270
Lead Sponsor Universidad Complutense de Madrid
Conditions Stage IV Periodontitis, Orthodontic Tooth Movement
Enrollment 28 participants
Start Date 2023-12-15
Primary Completion 2025-10 (estimated)
Study Completion 2026-01 (estimated)
Updated on ClinicalTrials.gov 2025-03-27