Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Myasthenia Gravis

During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on neuromuscular junction (NMJ) transmission and fatigability in adults with Generalized Myasthenia Gravis (gMG). The investigators will also test whether a relationship exists between NMJ transmission dysfunction and fatigability in gMG, which has long been presumed but never directly assessed. Participants will undergo clinical and electrophysiologic testing before and after the WB-EMS Exercise intervention. The WB-EMS Exercise intervention will be delivered 2 times per week for 4 weeks. Long-term follow up is optional. The hypotheses are (a) that the WB-EMS exercise will improve fatigability and NMJ transmission, and (b) that NMJ transmission dysfunction is related to fatigability.

NCT Number	NCT06064695
Lead Sponsor	University of Missouri-Columbia Collaborators: University of Kansas Medical Center
Conditions	Generalized Myasthenia Gravis
Enrollment	16 participants
Start Date	2023-07-12
Primary Completion	2025-04 (estimated)
Study Completion	2025-08 (estimated)
Updated on ClinicalTrials.gov	2025-04-10