Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery

Scoliosis correction surgery is associated with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and drug tolerance. In a recent trial, mini-dose esketamine and dexmedetomidine combination as a supplement to sufentanil significantly improved analgesia and subjective sleep quality after spinal correction surgery without increasing adverse events; however, the proportion of patients with moderate-to-severe pain remained high. The authors speculate that increasing esketamine dose in the combination may further improve analgesic effects.

NCT Number	NCT06062550
Lead Sponsor	Peking University First Hospital
Conditions	Scoliosis Correction, Esketamine, Dexmedetomidine, Postoperative Analgesia, Chronic Postsurgical Pain
Enrollment	312 participants
Start Date	2023-10-24
Primary Completion	2025-10-23 (estimated)
Study Completion	2026-10 (estimated)
Updated on ClinicalTrials.gov	2026-04-13