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Potassium, Hydration, Cardiovascular, and Kidney Study (PHACKs)

Study acronym: PHACKs
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated February 27, 2025 (before its estimated July 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Minor Study title expanded, about 1 wordv7
  2. Notable Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 1
    • Start date changed from estimate of Feb 2025 to Nov 6, 2024
    v6
  3. Notable Primary completion date: Dec 2025 to Jul 2026v5 Show 5 more changesShow less
    • Start date: Oct 2024 to Feb 2025
    • Study completion date: May 2026 to Jul 2027
    • Interventions: Water alone (Other), Water and Potassium supplementation (Dietary Supplement) to Water and Potassium supplementation (Dietary Supplement)
    • Study description shortened, about 12 words
    • Study arms: 3 to 2
  4. Notable Start date: Jun 2024 to Oct 2024v4
  5. Notable Start date: Nov 2023 to Jun 2024v3
  6. Minor Secondary endpoints: details revised at 2 of 11 entriesv2
  7. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Compared with White Adults, Non-Hispanic Black Adults are at an elevated risk of developing cardiovascular disease (CVD) and end stage chronic-kidney disease (CKD), two of the leading causes of death in the United States. Inadequate hydration status is associated with risk factors for both CVD and CKD. Prior data show that Black individuals are less likely to be adequately hydrated when compared with their White counterparts. Further, socioeconomic factors have been shown to influence hydration practices. Inadequate hydration influences certain hormones that regulate blood volume and impact blood pressure, but increasing potassium intake may provide some positive effects on normalizing these hormones and blood pressure. Black adults, in particular, are more likely to consume less potassium, have inadequate hydration, and tend to have higher blood pressure. As such, there is a critical need for effective strategies to address racial disparities in hydration and resultant health consequences; as well as establish the role of socioeconomic factors contributing to hydration. Therefore, the investigators are seeking to test the investigators' central hypothesis that water with a potassium supplement will improve hydration and cardiovascular health in young White adults (n = 20, 10 females, 10 males), and to a greater extent in young Black Adults (n = 20, 10 females, 10 males. The investigators will assess measures of blood pressure, arterial stiffness, and biomarkers in the urine and blood samples prior to and following a 14-day hydration intervention of 1) bottled water and 2) bottled water with potassium supplementation (2000mg potassium/day).
Trial Details
NCT Number NCT06062017
Lead Sponsor Auburn University
Collaborators: Indiana University
Conditions
(from sponsor)
Blood Pressure, Hydration, Vascular Disease Risk
Enrollment 40 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov