Clinical Trial

Advancing Transplantation Outcomes in Children

Study acronym: ADVANTage
Recruiting Phase 2
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Summary
This is a pediatric kidney transplant study comparing the safety and efficacy of an immunosuppressive regimen of belatacept and sirolimus to tacrolimus and Mycophenolate Mofetil (MMF). Two hundred participants will be randomized (1:1) to one of two groups within 24 hours following the transplant procedure. The duration of the study from time of transplant to the primary endpoint is 12-24 months.
Protocol Amendment History 21 amendments
This ClinicalTrials.gov record has been amended 21 times since 2023-09-20; most recent amendment 2026-05-19.
Status change: Not Yet Recruiting → Recruiting 2024-04-26
Trial Details
NCT Number NCT06055608
Lead Sponsor National Institute of Allergy and Infectious Diseases (NIAID)
Conditions Kidney Transplant
Enrollment 200 participants
Start Date 2024-05-22
Primary Completion 2028-06-30 (estimated)
Study Completion 2028-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-20