Diabetes Remission and Hypoabsorptive Bariatric Surgery

Bariatric surgery is the most effective treatment to achieve type 2 Diabetes Mellitus (DM) remission in patients with severe obesity. However, there is little evidence of the effectiveness and pathophysiological mechanisms involved in metabolic improvement after hypoabsortive tecniques such as duodenal switch (DS), single anastomosis duodenal switch (SADI-S) or minigastric bypass (MGB). We have designed a randomized study to compare type 2 diabetes remission after the 3 bariatric procedures in patients with severe obesity (BMI \> 45kg/m2) and to study the implication of gastrointestinal hormones, bile acids and gut microbiota in metabolic improvement in each procedure.

NCT Number	NCT06043245
Lead Sponsor	Hospital Universitari de Bellvitge Collaborators: Instituto de Salud Carlos III
Conditions	Severe Obesity, Diabetes Mellitus, Type 2, Bariatric Surgery Candidate
Enrollment	66 participants
Start Date	2023-06-21
Primary Completion	2026-09-30 (estimated)
Study Completion	2027-09-30 (estimated)
Updated on ClinicalTrials.gov	2023-09-21