International Registry of Congenital Portosystemic Shunt (IRCPSS)

Congenital Portosystemic Shunt (CPSS) is a rare condition important by the multiplicity and severity of associated complications. CPSS is venous anomaly in which blood coming from the intestines only partially passes through the liver. This leads to the accumulation of potentially toxic factors that cause systemic effects. Complications vary among the individuals, and currently, it is challenging to predict which individuals will develop severe complications. The IRCPSS registry is established with the aim of centralizing detailed clinical follow-up and biological information from participants around the world who suffer from Congenital Portosystemic Shunt (CPSS). A multidisciplinary consortium of experts is collaborating to enhance our understanding of the prevalence, natural history, individual risks, and physiopathology of the disease through the IRCPSS registry.

NCT Number	NCT06041906
Lead Sponsor	Prof. Valérie Mc Lin Collaborators: European Society of Pediatric Gastroenterology, Hepatology and Nutrition, European Association for the Study of the Liver (EASL), Fondation Andrea Ferrari
Conditions	Congenital Portosystemic Shunt, CPSS (Congenital Portosystemic Shunt)
Enrollment	500 participants
Start Date	2018-04-26
Primary Completion	2026-10-26 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-06-18