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Investigation of Locus Coeruleus Function in Sustained Attention

Study acronym: LC
StatusRecruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary and study completion dates: Dec 30, 2025 to Dec 19, 2026v6
  2. Primary completion date: Aug 1, 2025 to Dec 30, 2025v5
  3. Primary completion date: Aug 2024 to Aug 1, 2025
    • Study completion date: Aug 2024 to Dec 30, 2025
    v4
  4. Site contact updatedv3
  5. Start date changed from estimate of Oct 2023 to Oct 1, 2023v2
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The norepinephrine-producing locus coeruleus (LC) is thought to be central to a wide array of cognitive functions, like attention and goal pursuit, and has been implicated in dysfunctions including attention deficit hyperactivity disorder and schizophrenia. The goal of this proposal is to develop methods that permit measurement of activity in the human LC. Because the LC is small and located in the pons, the Investigators will use high resolution magnetic resonance imaging techniques tailored to the brainstem environment, including neuromelanin-sensitive images shown to delineate the LC, combined with pharmacological manipulation to confirm the location of functional activity.
Trial Details
NCT Number NCT06041048
Lead Sponsor University of California, Davis
Conditions
(from sponsor)		 Attention - no Condition is Being Assessed - Healthy Adults
Enrollment 40 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov