Prevalence of Tapia's Syndrome in Weaning Unit

Tapia syndrome is a rare and poorly understood pathology. It is defined by a concomitant attack of the recurrent (branch of X) and hypoglossal (XII) nerves of peripheral or central origin. It is characterized by the paralysis of a vocal cord and the ipsilateral half of tongue. This damage is most often unilateral but it can also be bilateral. It results in dysphonia and swallowing disorders. Tapia syndrome is a rare and poorly understood pathology. To date, less than 100 cases have been described in the literature. Previous works are mainly case reports and literature reviews. No prevalence study has been performed to date. Furthermore, disagreements persist regarding the semiology. Indeed, the involvement of the soft palate is not always described.

NCT Number	NCT06033144
Lead Sponsor	Hopital Forcilles
Conditions	Tapia's Syndrome
Enrollment	247 participants
Start Date	2023-04-07
Primary Completion	2025-11-07 (estimated)
Study Completion	2027-04-07 (estimated)
Updated on ClinicalTrials.gov	2025-09-15