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NCT06031272 · ClinicalTrials.gov record · last posted 2026-08-17

Pausing Antiretroviral Treatment Under Structured Evaluation

Study acronym: PAUSE
StatusCompleted
PhasePhase 1
Started2024-05-28
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from the ClinicalTrials.gov record
The main purpose of this study is to see if it is safe to give the study antibodies (3BNC117-LS-J and 10-1074-LS-J) by intravenous infusion to people with HIV (PWH), and to see if they cause any side effects. In addition, to see how the study antibodies affect the level of HIV in the blood when participants are not taking regular HIV treatment for an extended period. This extended period of not taking regular HIV treatment is called an analytical treatment interruption (ATI).

Protocol amendment history 1 change detected by DataLookout

2026-08-18
Trial completed
Trial Details
NCT Number NCT06031272
Lead Sponsor Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Collaborators: National Institute of Allergy and Infectious Diseases (NIAID)
Conditions HIV-1-infection
Enrollment 32 participants
Start Date 2024-05-28
Primary Completion 2025-10-14 (estimated)
Study Completion 2026-06-25 (estimated)
Updated on ClinicalTrials.gov 2026-08-17