Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients

The purpose of this study is to assess a new test to detect antibodies which may form following kidney transplant. These antibodies can be difficult to detect as they do not cause any symptoms but can lead to kidney damage. A new blood test will be performed alongside existing antibody tests to see how well the test functions in comparison and to see how well it is able to distinguish between inflammation caused by antibodies and other sorts of inflammation such as a urinary tract infection. The investigators also want to determine whether it is predictable whom will develop antibodies after a transplant and use these results to change the current way patients are monitored for antibodies after receiving a transplant. In addition to this, the investigators want to establish if patients over 60 years of age are relatively protected against immunological events such as rejection compared to patients who are under 60 years of age. The results could potentially lead to using a different immunosuppression regime based on which population age group patients belong to and lowering the risks associated with these drugs.

NCT Number	NCT06025240
Lead Sponsor	Liverpool University Hospitals NHS Foundation Trust Collaborators: Kidney Research United Kingdom
Conditions	Kidney Transplant, Renal Transplant Failure, Kidney Transplant Rejection, Frailty, Kidney Transplant; Complications, Transplant Dysfunction, Diagnosis, Renal Transplant
Enrollment	282 participants
Start Date	2023-10-13
Primary Completion	2025-10-13 (estimated)
Study Completion	2026-10-13 (estimated)
Updated on ClinicalTrials.gov	2024-08-30