Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome

This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU). There are different approaches to sedation which may have advantages and disadvantages. During the study patients will receive both intravenous and inhaled volatile sedation (similar to anaesthetic 'gases' used for general anaesthesia) and the drive to breath, breathing efforts and function of the lung will be assessed.

NCT Number	NCT06014138
Lead Sponsor	Guy's and St Thomas' NHS Foundation Trust Collaborators: Sedana Medical
Conditions	Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, Sedation Complication
Enrollment	20 participants
Start Date	2023-11-01
Primary Completion	2027-07-31 (estimated)
Study Completion	2027-07-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-04