Prehabilitation for Colorectal Cancer Patients With Low Functional Capacity and Malnutrition

Despite multi-modal prehabilitation (nutrition, exercise, and psychosocial interventions), 60% of older elective colorectal cancer surgery patients with poor physical function were unable to reach a minimum preoperative 400m six-minute walking distance (6MWD), a prognostic cut-point. Compared to the patients that attained \>400m 6MWD preoperatively, twice as many of \<400m patients were malnourished. Malnutrition has long been associated with worse functioning (e.g., physical, immune). The investigators hypothesize that for nutritionally deficient patients, the etiology for their poor physical function is malnutrition. Correction of malnutrition alone might thus be sufficient to achieve a 400m 6MWD before surgery and improve patient outcomes.

NCT Number	NCT05999370
Lead Sponsor	McGill University Collaborators: McGill University Health Centre/Research Institute of the McGill University Health Centre
Conditions	Prehabilitation, Malnutrition, Physical Functional Performance
Enrollment	60 participants
Start Date	2022-01-31
Primary Completion	2026-12 (estimated)
Study Completion	2026-12 (estimated)
Updated on ClinicalTrials.gov	2025-05-09