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Mechanisms of Action on Rectal Motricity of Intrarectal Botulinum Toxin Injections

Study acronym: MECA-TOX
StatusRecruiting
PhasePhase 3
Started2025-04-15
View on ClinicalTrials.gov ↗

Amendment history

2026-01-20
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2023-12-01→confirmed 2025-04-15
Study sitesdetails revised at 1 of 1 site
2023-08-10
Original filing
Previous studies have demonstrated the efficacy of this treatment in certain patients suffering from fecal incontinence, but it is not yet reimbursed in this indication as it is still in the evaluation phase. Indeed, little is known about botulinum toxin mechanisms of action. The aim of this study is to better understand the mechanisms of action of intra-rectal botulinum toxin injections, so that the investigators can identify the patients most likely to benefit from this treatment in the future.
Trial Details
NCT Number NCT05998187
Lead Sponsor University Hospital, Rouen
Conditions Fecal Incontinence
Enrollment 21 participants
Start Date 2025-04-15
Primary Completion 2027-06-01 (estimated)
Study Completion 2027-12-01 (estimated)
Updated on ClinicalTrials.gov 2026-01-22