Mechanisms of Action on Rectal Motricity of Intrarectal Botulinum Toxin Injections

Previous studies have demonstrated the efficacy of this treatment in certain patients suffering from fecal incontinence, but it is not yet reimbursed in this indication as it is still in the evaluation phase. Indeed, little is known about botulinum toxin mechanisms of action. The aim of this study is to better understand the mechanisms of action of intra-rectal botulinum toxin injections, so that the investigators can identify the patients most likely to benefit from this treatment in the future.

NCT Number	NCT05998187
Lead Sponsor	University Hospital, Rouen
Conditions	Fecal Incontinence
Enrollment	21 participants
Start Date	2025-04-15
Primary Completion	2027-06-01 (estimated)
Study Completion	2027-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-22