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Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences

Study acronym: STARS
StatusRecruiting
PhasePhase 4
Started
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Record History

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  1. Notable Trial status: Suspended to Recruiting
    • Primary and study completion dates: Dec 1, 2025 to Dec 1, 2027
    • Site details revised
    v8
  2. Stopped Trial status: Recruiting to Suspended Sponsor's reason: No recruitment has occurred, will start in early 2025
    • Primary and study completion dates: Sep 1, 2024 to Dec 1, 2025
    • Site details revised
    v7
  3. Notable Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Oct 15, 2023 to Oct 31, 2023
    • Site details revised
    v6
  4. Minor Re-verified, no change to tracked fieldsv5
  5. Notable Start date: Sep 1, 2023 to Oct 15, 2023v4
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  1. Minor Study title revisedv3
  2. Minor Re-verified, no change to tracked fieldsv2
  1. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The main purpose of this interventional study is to examine differences in resting blood pressure control between healthy males and females. The main questions it aims to answer are: 1. Are there sex differences in the communication between the sympathetic nervous system (also known as the "fight or flight" response) and peripheral blood vessels (which influence systemic blood pressure)? 2. What is the role of specific vascular receptors that respond to sympathetic signals, and is it different between males and females? Participants will complete one study visit of approximately 3 hours where they will: * Have a blood sample taken to measure circulating sex hormone and sympathetic transmitters. * Receive very small doses of medications commonly used to adjust blood pressure through an artery in their arm. The effects of these medications will be short-acting and localized to the forearm. * Have their sympathetic nervous activity directly measured through two very small needles (similar to acupuncture needles) in the side of their leg. * Have their blood pressure and heart rate recorded, and forearm blood flow measured using ultrasound.
Trial Details
NCT Number NCT05997732
Lead Sponsor University of Alberta
Conditions
(from sponsor)
Vasoconstriction, Vasodilation
Related terms Aneurysm
Enrollment 30 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov