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A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma

Study acronym: Glo-BNHL
StatusRecruiting
PhasePhase 2/3
Started
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Record History

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  1. Site details revised at 5 of 11 sitesv6
  2. Study sites: 3 to 11v5
  3. Trial status: Active, Not Recruiting to Recruiting
    • Study sites: 1 to 3
    v4
  4. Trial status: Not Yet Recruiting to Active, Not Recruitingv3 Show 5 more changesShow less
    • Study sites: 0 to 1
    • Primary completion date: May 2031 to May 1, 2031
    • Study completion date: May 2033 to May 1, 2033
    • Start date changed from estimate of May 2024 to May 2, 2024
    • Collaborators revised (4)
  5. Primary completion date: Oct 2030 to May 2031
    • Start date: Oct 2023 to May 2024
    • Study completion date: Oct 2032 to May 2033
    v2
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The Glo-BNHL trial is trying to find better medicines for children and young people with B-cell non-Hodgkin Lymphoma (B-NHL) that does not go away (refractory B-NHL) or does but comes back again (relapsed B-NHL). B-NHL is a type of cancer that develops inside or outside of lymph nodes (glands) and organs such as the liver or spleen. Examples of B-NHL are Burkitt Lymphoma and Diffuse Large B Cell Lymphoma, which may be other names used to describe this type of cancer. It is very difficult to cure relapsed or refractory B-NHL. The medicines used now are very powerful with many side effects and only cure around 30 in every 100 children treated. It is very important that investigators quickly find better medicines for these children and young people. The Glo-BNHL trial will include three groups of children and young people, each given a new medicine (either alone or with chemotherapy). The investigators are looking to make sure the new medicines are safe and that they work to treat the cancer. If the medicine in one group does not work for a child in the trial, then they may be able to join a different group to have another new medicine. Experts from around the world will carefully pick the medicines most likely to be helpful to be part of the trial. If one of the new medicines seems not to be working as well as hoped then the investigators will take it out of the trial as soon as possible. This will let other new medicines be added to the trial and tested. If a medicine does seem to be working well, then it will continue in the trial to make sure it really is the most useful medicine available. Children from around the world will be invited to take part in the trial. The investigators will then check on them for at least two years after they finish the trial treatment to look for possible side effects of the new medicine.
Trial Details
NCT Number NCT05991388
Lead Sponsor University of Birmingham
Collaborators: Cancer Research UK, Fight Kids Cancer, Regeneron Pharmaceuticals, ADC Therapeutics S.A.
Conditions
(from sponsor)		 B-cell Non Hodgkin Lymphoma
Related terms Lymphoma, B-Cell
Enrollment 210 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov