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The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium

Study acronym: RAPID-II
StatusRecruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. Re-verified, no change to tracked fieldsv5
  2. Study sites: 1 to 2 Collaborators expanded, about 3 wordsv4 Show 1 more changeShow less
    • Collaborators expanded, about 3 words

    See this version in full on ClinicalTrials.gov ↗

  3. Trial status: Not Yet Recruiting to Recruiting Start date changed from estimate of Sep 1, 2023 to Sep 3, 2023 · Site details revisedv3 Show 2 more changesShow less
    • Start date changed from estimate of Sep 1, 2023 to Sep 3, 2023
    • Site details revised
  4. Start date: Aug 1, 2023 to Sep 1, 2023v2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Patients over the age of 65 years are at increased risk for developing delirium after noncardiac surgeries, resulting in increased morbidity and mortality. The prevention of postoperative delirium has been classified as a public health priority. However, so far data regarding possible intraoperative interventions to reduce the incidence of postoperative delirium is very scarce. Due to the more rapid wash-in and wash-out times of desflurane as compared to sevoflurane or propofol it seems reasonable that desflurane might be beneficial for the prevention of postoperative delirium. Therefore, we evaluate the effect of maintenance of anesthesia using desflurane, sevoflurane or propofol on postoperative delirium in elderly patients undergoing moderate- to high-risk major noncardiac surgery.
Trial Details
NCT Number NCT05990790
Lead Sponsor Medical University of Vienna
Collaborators: Medical University Innsbruck
Conditions Postoperative Delirium, Major Noncardiac Surgery, Postoperative Cognitive Dysfunction
Enrollment 1,332 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov