The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium

Patients over the age of 65 years are at increased risk for developing delirium after noncardiac surgeries, resulting in increased morbidity and mortality. The prevention of postoperative delirium has been classified as a public health priority. However, so far data regarding possible intraoperative interventions to reduce the incidence of postoperative delirium is very scarce. Due to the more rapid wash-in and wash-out times of desflurane as compared to sevoflurane or propofol it seems reasonable that desflurane might be beneficial for the prevention of postoperative delirium. Therefore, we evaluate the effect of maintenance of anesthesia using desflurane, sevoflurane or propofol on postoperative delirium in elderly patients undergoing moderate- to high-risk major noncardiac surgery.

NCT Number	NCT05990790
Lead Sponsor	Medical University of Vienna Collaborators: Medical University Innsbruck
Conditions	Postoperative Delirium, Major Noncardiac Surgery, Postoperative Cognitive Dysfunction
Enrollment	1,332 participants
Start Date	2023-09-03
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-04-30