Brain Activity Among Children With Overactive Bladder and Daytime Urinary Incontinence and Healthy Children

The aim of this study is to investigate whether the activity in brain areas controlling the bladder is different among children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and gender-matched healthy children without bladder symptoms. Moreover, the aim is to investigate if sacral transcutaneous electric nerve stimulation (TENS) has a central mechanism of action. Children with OAB and DUI will be recruited from involved pediatric departments, and functional magnetic resonance imaging (fMRI) will be performed before and after 10 weeks of sacral TENS. In healthy children without bladder symptoms, only the baseline fMRI will be performed.

NCT Number	NCT05989646
Lead Sponsor	Aalborg University Hospital Collaborators: Aarhus University Hospital, Regional Hospital West Jutland, Regionshospital Nordjylland
Conditions	Urinary Incontinence, Daytime Wetting, Urination Disorders, Urination Involuntary, Urologic Diseases, Lower Urinary Tract Symptoms, Urological Manifestations, Behavioral Symptoms +2 more
Enrollment	65 participants
Start Date	2021-05-05
Primary Completion	2027-12 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-04-20