Clinical Trial

Menopause Related Influences on Leukocyte Distribution, Monocyte Function and Platelet Reactivity

Recruiting
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Record status
This record was last updated August 14, 2023 (before its estimated December 2025 completion). Its status may not reflect the trial's current state.
Summary
Women and men show marked differences in cardiovascular risk profile and outcome. Women experience fewer cardiovascular events than men before menopause, but this relationship seems to reverse at menopause. These disparities are probably due to hormonal factors, especially the female sex hormone estrogen seems to have a protective influence on the development of atherosclerotic plaques premenopausal. The underlying mechanisms of the effect of estrogens on the vessel wall are still insufficiently investigated. In this study, menopause related effects on leukocyte distribution and function as well on platelets and their aggregational response will be evaluated.
Trial Details
NCT Number NCT05985447
Lead Sponsor Heinrich-Heine University, Duesseldorf
Conditions Arteriosclerosis, Acute Myocardial Infarction, Cardiovascular Events, Menopause
Enrollment 180 participants
Start Date 2022-03-07
Primary Completion 2025-12 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2023-08-14