Imagery Rescripting as Treatment for Depression

The goal of this multiple baseline case series study is to test Imagery Rescripting in depression. The main question\[s\] it aims to answer are: * does Imagery Rescripting lead to a reduction of depression and of believability of negative beliefs held by the participants? * does Imagery Rescripting also leads to reductions in worrying and brooding? * Participants will wait for 6-10 weeks (to assess time effects without treatment), followed by 5 weekly preparation sessions, 8-12 weekly Imagery Rescripting sessions, and 5 weeks post-treatment. * Participants will rate the believability of 3-5 core dysfunctional beliefs related to their depression as well as 2 items assessing depression severity on a weekly basis. In addition, they will fill out more extensive questionnaires on depression, worry and brooding before each phase, as well as at 5 weeks post-treatment, and 6 and 12 months follow-up.

NCT Number	NCT05976945
Lead Sponsor	University of Amsterdam Collaborators: Academic Center for Trauma and Personality
Conditions	Major Depressive Disorder, Persistent Depressive Disorder
Enrollment	10 participants
Start Date	2023-08-10
Primary Completion	2026-08-01 (estimated)
Study Completion	2027-08-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-06