COAgulation Disorders in Ischaemic and Haemorrhagic Stroke

In this study the investigators will assess both procoagulant and anticoagulant pathways using thrombin generation and platelet function tests; as well as neuronal ischemia using cell free DNA in all patients presenting with ischaemic and haemorrhagic stroke (including aneurysmal subarachnoid haemorraghe). Also the cross-talk between inflammation and thrombosis, so-called thrombo-inflammation is further investigated. As such the investigators aim to characterise the patient's coagulation profile before administration of any treatment. By assessing these pathways the investigators strive to detect specific markers to predict vital and functional outcome at 3 months in these patients. Finally the investigators may provide new pathophysiological insights in the course of disease following these events that can possibly improve future therapeutic strategies.

NCT Number	NCT05974111
Lead Sponsor	Ziekenhuis Oost-Limburg Collaborators: Synapse bv
Conditions	Ischemic Stroke, Haemorrhagic Stroke, Aneurysmal Subarachnoid Hemorrhage
Enrollment	350 participants
Start Date	2023-05-02
Primary Completion	2025-05-02 (estimated)
Study Completion	2025-08-31 (estimated)
Updated on ClinicalTrials.gov	2024-11-14