Clinical Trial

Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention

Study acronym: PRISM
Recruiting
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Summary
The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) and reduce polysubstance use among patients with OUD and polysubstance use in underserved areas. The intervention is based on behavioral activation (BA) and is specifically designed to be implemented by a trained peer recovery specialist. In this hybrid, Type-1 effectiveness-implementation randomized controlled trial (RCT), the investigators will evaluate the effectiveness and implementation of Peer Activate vs. treatment as usual (TAU) over twelve months.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2023-07-25; most recent amendment 2026-04-21.
Trial Details
NCT Number NCT05973838
Lead Sponsor University of Maryland, College Park
Collaborators: University of Maryland, Baltimore, Weill Medical College of Cornell University, National Institute on Drug Abuse (NIDA)
Conditions Polysubstance Addiction, Opioid Medication Assisted Treatment, Treatment Adherence, Retention in Care, Substance-Related Disorders
Enrollment 160 participants
Start Date 2023-06-15
Primary Completion 2027-07-01 (estimated)
Study Completion 2027-09-01 (estimated)
Updated on ClinicalTrials.gov 2026-04-27