Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade Glioma

Low-grade glioma (LGG) represent typically slowly growing primary brain tumors with world health organization (WHO) grade I or II who affect young adults around their fourth decade. Radiological feature on MRI is a predominantly T2 hyperintense signal, LGG show typically no contrast uptake. Radiotherapy plays an important role in the treatment of LGG. However, not least because of the good prognosis with long term survivorship the timing of radiotherapy has been discussed controversially. In order to avoid long term sequelae such as neurocognitive impairment, malignant transformation or secondary neoplasms initiation was often postponed as long as possible

NCT Number	NCT05964569
Lead Sponsor	University Hospital Heidelberg
Conditions	Low Grade Glioma
Enrollment	120 participants
Start Date	2023-11-11
Primary Completion	2026-11-11 (estimated)
Study Completion	2028-11-11 (estimated)
Updated on ClinicalTrials.gov	2024-01-05