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Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

Study acronym: CPT+RP
StatusRecruiting
PhasePhase 2
Started
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Record History

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  1. Site contacts updated at 1 of 2 sites
    • Eligibility criteria expanded, about 3 words
    v8
  2. Eligibility criteria expanded, about 3 wordsv7
  3. Eligibility criteria shortened, about 4 wordsv6
  4. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 2
    • Start date changed from estimate of Mar 1, 2024 to Apr 1, 2024
    v5
  5. Primary completion date: Jun 2027 to Jun 30, 2027
    • Study completion date: Jul 2028 to Jul 31, 2028
    v4
Show 2 earlier versionsHide 2 earlier versions
  1. Start date: Jan 2024 to Mar 1, 2024v3
  2. Lead sponsor: University of Houston to Texas A&M Universityv2 Show 4 more changesShow less
    • Start date: Oct 2023 to Jan 2024
    • Primary completion date: Feb 2027 to Jun 2027
    • Study completion date: Mar 2028 to Jul 2028
    • Collaborators reordered
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Texas A&M University
34 trials monitored
See 5 trials at risk
PTSD
889 trials monitored
See 54 trials at risk
The goal of this clinical trial is to test the efficacy of a novel integrative cognitive-behavioral intervention in patients with posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Specific Aim 1: Examine the efficacy of CPT-RP, as compared to RP alone, in reducing alcohol frequency (percent days drinking) and quantity (drinks per drinking day) as measured by the Timeline Follow-Back (TLFB). Specific Aim 2: Examine the efficacy of CPT-RP, as compared to RP alone, in reducing PTSD symptoms as measured by the Clinician Administered PTSD Scale (CAPS-5). Specific Aim 3: Use ecological momentary assessment (EMA) to evaluate intervention effects on daily alcohol-related cognitions and behaviors through real-time associations with PTSD symptomatology and distress tolerance. Researchers will compare integrative CPT+RP with RP-alone to see if CPT+RP is more efficacious in reducing alcohol use and PTSD symptom severity.
Trial Details
NCT Number NCT05959434
Lead Sponsor Texas A&M University
Collaborators: Medical University of South Carolina, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Conditions
(from sponsor)		 Posttraumatic Stress Disorder, Alcohol Use Disorder
Related terms Alcohol Drinking, Alcoholism, Stress Disorders, Post-Traumatic, Wounds and Injuries
Enrollment 200 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov