Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

The goal of this clinical trial is to test the efficacy of a novel integrative cognitive-behavioral intervention in patients with posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Specific Aim 1: Examine the efficacy of CPT-RP, as compared to RP alone, in reducing alcohol frequency (percent days drinking) and quantity (drinks per drinking day) as measured by the Timeline Follow-Back (TLFB). Specific Aim 2: Examine the efficacy of CPT-RP, as compared to RP alone, in reducing PTSD symptoms as measured by the Clinician Administered PTSD Scale (CAPS-5). Specific Aim 3: Use ecological momentary assessment (EMA) to evaluate intervention effects on daily alcohol-related cognitions and behaviors through real-time associations with PTSD symptomatology and distress tolerance. Researchers will compare integrative CPT+RP with RP-alone to see if CPT+RP is more efficacious in reducing alcohol use and PTSD symptom severity.

NCT Number	NCT05959434
Lead Sponsor	Texas A&M University Collaborators: Medical University of South Carolina, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Conditions	Posttraumatic Stress Disorder, Alcohol Use Disorder
Enrollment	200 participants
Start Date	2024-04-01
Primary Completion	2027-06-30 (estimated)
Study Completion	2028-07-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-24