Treatment of Cognitive Deficits in Multiple Sclerosis With High-Definition Transcranial Direct Current Stimulation

The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., presupplementary motor area) thought to aid in memory will improve verbal retrieval in multiple sclerosis patients. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures. Additionally, the study will examine the degree to which baseline assessments of cognition and concussion history predict responses to treatment over time, both on assessments administered within the intervention period and at follow-up.

NCT Number	NCT05958381
Lead Sponsor	The University of Texas at Dallas Collaborators: University of Texas Southwestern Medical Center
Conditions	Multiple Sclerosis, Relapsing-Remitting
Enrollment	100 participants
Start Date	2023-10-18
Primary Completion	2027-06-29 (estimated)
Study Completion	2027-06-29 (estimated)
Updated on ClinicalTrials.gov	2026-08-14