Clinical Trial

Guanfacine Extended-release for Adolescents With Cannabis Use

Study acronym: GRACE
Recruiting Phase 2
View on ClinicalTrials.gov →
Record status
This record was last updated July 31, 2025 (before its estimated December 31, 2025 completion). Its status may not reflect the trial's current state.
Summary
A randomized controlled trial to assess the efficacy of extended-release guanfacine to reduce cannabis use frequency in young people with cannabis use disorder following a period of monitored abstinence.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2023-07-16; most recent amendment 2025-07-29.
Status change: Not Yet Recruiting → Recruiting 2023-08-21
Trial Details
NCT Number NCT05957848
Lead Sponsor Orygen
Collaborators: Youth Support and Advocacy Service, University of Melbourne
Conditions Cannabis Use Disorder
Enrollment 100 participants
Start Date 2023-07-27
Primary Completion 2025-12-31 (estimated)
Study Completion 2026-06-30 (estimated)
Updated on ClinicalTrials.gov 2025-07-31