Clinical Trial

Insight Into Hippocampal Neuroplasticity in Schizophrenia by Investigating Molecular Pathways During Physical Training

Study acronym: BrainTrain
Recruiting
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Summary
Aerobic endurance training has shown positive effects on symptoms, cognition, daily functioning, and the structure of the hippocampus in patients with schizophrenia. The study investigates genetic and epigenetic influences on neuroplastic changes following three months of endurance training. A control group performs flexibility, strength, and balance training. The main objective is to examine the association between a genetic risk score for schizophrenia and volume increase in the CA4/DG region of the hippocampus. Additional goals include examining changes in synapses, brain structure, function, and metabolism, as well as clinical symptoms and cognitive performance.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2023-07-13.
Status change: Not Yet Recruiting → Recruiting 2023-11-17
Trial Details
NCT Number NCT05956327
Lead Sponsor LMU Klinikum
Collaborators: German Research Foundation
Conditions Schizophrenia, Neuronal Plasticity, Exercise
Enrollment 156 participants
Start Date 2023-09-29
Primary Completion 2026-09 (estimated)
Study Completion 2026-09 (estimated)
Updated on ClinicalTrials.gov 2023-11-21