Clinical Trial

Project Khanya: Peer-Delivered Intervention to Improve HIV Medication Adherence and Substance Use in South Africa

Active, Not Recruiting
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Summary
The purpose of this study is to evaluate a stepped care behavioral intervention for HIV medication adherence and substance use ("Khanya") integrated into an HIV primary care setting in South Africa. The intervention is specifically designed to be implemented by non-specialist counselors with lived substance use experience (i.e., peers), using a task sharing, stepped care model in local primary care clinics. The Khanya stepped care package will be compared to usual care, enhanced with referral to a local outpatient substance use treatment program (Enhanced Standard of Care - ESOC) over 12 months.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2023-06-27; most recent amendment 2026-05-05.
Status change: Recruiting → Active, Not Recruiting 2026-05-05
Trial Details
NCT Number NCT05933226
Lead Sponsor University of Maryland, College Park
Collaborators: University of Cape Town, National Institute on Drug Abuse (NIDA), Weill Medical College of Cornell University, University of Miami
Conditions Human Immunodeficiency Virus, Alcohol-Related Disorders, Drug Use, Substance Use
Enrollment 160 participants
Start Date 2023-06-21
Primary Completion 2027-02 (estimated)
Study Completion 2027-02 (estimated)
Updated on ClinicalTrials.gov 2026-05-07